Comparative distribution of misonidazole and its amine metabolite in female Swiss Webster mice
The distribution of misonidazole and its terminal reduction product 1-(2-amino-1-imidazolyl)-3-methoxy-2-propanol (misoamine) were compared in female Swiss Webster mice to determine if either misonidazole or misoamine is distributed to peripheral nerves. Female Swiss Webster mice received a 100 mg/kg (5 ..mu..Ci/..mu..mole) i.p. dose of either /sup 3/H-misonidazole or /sup 3/H-miso-amine and the distribution of radioactivity was determined in various tissues including sciatic nerves and other myelinated nerves. Misonidazole produced higher initial tissue concentrations of radioactivity than did miso-amine. The relative tissue concentrations of radioactivity produced by misonidazole or miso-amine were similar, although not identical, 48 hours after administration of the drugs. Both sciatic and other myelinated nerves were found to retain radioactivity following the administration of either misonidazole or miso-amine.
- Research Organization:
- Univ. of New Mexico, Albuquerque
- OSTI ID:
- 5354970
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
METABOLITES
TISSUE DISTRIBUTION
MISONIDAZOLE
TOXICITY
NERVES
AMINES
MICE
RADIOSENSITIVITY EFFECTS
SCIATIC NERVE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
DISTRIBUTION
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIZERS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)