Kinetics of cellular inactivation by fractionated and hyperfractionated irradiation in Lewis lung carcinoma
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The kinetics of cellular inactivation by fractionated irradiation in Lewis lung carcinoma was studied in the dose range of 2.3 to 6.5 Gy per fraction. Regimens of one and two fractions per day for 10 days were compared. The number of clonogenic tumor cells was determined using an in vitro soft-agar colony assay. Under the experimental conditions used, the fraction of tumor cells inactivated per day was only dependent on the total dose per day, i.e., the cellular response was the same whether the daily dose was given in one or two fractions. Thus, the two fraction per day regimen was more effective than expected from calculations based on acute in vivo radiation dose-survival curves. This result could be explained if the clonogenic tumor cells were less hypoxic during the two fractions per day regimen than the one fraction per day schedule.
- Research Organization:
- Institute of Cancer Research, Sutton, England
- OSTI ID:
- 5354966
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:6; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
DISEASES
DNA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
GAMMA RADIATION
INACTIVATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LUNGS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RESPIRATORY SYSTEM
SURVIVAL CURVES
TUMOR CELLS
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
DISEASES
DNA
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
GAMMA RADIATION
INACTIVATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LUNGS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RESPIRATORY SYSTEM
SURVIVAL CURVES
TUMOR CELLS
YEARS LIVING RADIOISOTOPES