Radiotherapy of the rhabdomyosarcoma R1H of the rat: kinetics of cellular inactivation by fractionated irradiation

Journal Article · Mon Feb 01 04:00:00 EST 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90439-7· OSTI ID:5352427

Vogler, H; Beck-Bornholdt, H P

The kinetics of cellular inactivation by fractionated irradiation in the R1H rhabdomyosarcoma of the rat was studied in the dose range of 1.07 to 12.50 Gy per fraction. Regimens of 1, 3, 5, 7, and 10 fractions per week for several weeks were compared. The number of clonogenic tumor cells per tumor in the course of the different treatment schedules was determined using an in vitro colony assay. The results show that the proliferation of clonogenic tumor cells is decelerated in the course of a fractionated radiotherapy. The deceleration persists for several days after end of treatment, until accelerated repopulation is initiated. The fraction of tumor cells inactivated per week was only dependent on the total dose per week, that is the cellular response was the same whether the weekly dose was applied in 1,3,5,7, or 10 fractions. Thus, the fractionation regimens were considerably more effective than expected from calculations based on single-dose in situ survival curves.

• Research Organization: Univ. of Hamburg (Germany, F.R.)
• OSTI ID: 5352427
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 14:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
ANIMAL CELLS
ANIMALS
CELL CULTURES
CELL PROLIFERATION
CLONE CELLS
DISEASES
DOSES
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
MATHEMATICAL LOGIC
MEDICINE
MYOSARCOMAS
NEOPLASMS
NUCLEAR MEDICINE
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
RATS
RHABDOMYOSARCOMAS
RODENTS
SARCOMAS
SURVIVAL CURVES
THERAPY
TUMOR CELLS
VERTEBRATES