Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.12.4614· OSTI ID:5352641

Dracopoli, N C; Harnett, P; Bale, S J; Stanger, B Z; Tucker, M A; Housman, D E; Kefford, R F ^[1]

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1. Massachusetts Institute of Technology, Cambridge (USA)

The gene for familial malignant melanoma and its precursor lesion, the dysplastic nevus, has been assigned to a region of the distal short arm of chromosome 1, which is frequently involved in karyotypic abnormalities in melanoma cells. The authors have examined loci on chromosome 1p for loss-of-constitutional heterozygosity in 35 melanomas and 21 melanoma cell lines to analyze the role of these abnormalities in melanocyte transformation. Loss-of-heterozygosity at loci on chromosome 1p was identified in 15/35 (43%) melanomas and 11/21 (52%) melanoma cell lines. Analysis of multiple metastases derived from the same patient and of melanoma and lymphoblastoid samples from a family with hereditary melanoma showed that the loss-of-heterozygosity at loci on distal 1p is a late event in tumor progression, rather than the second mutation that would occur if melanoma were due to a cellular recessive mechanism. Comparisons with neuroblastoma and multiple endocrine neoplasia (MEN2) suggest that the frequent 1p loss-of-heterozygosity in these malignancies is a common late event of neuroectodermal tumor progression.

• OSTI ID: 5352641
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:12; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MELANOMAS
CHROMOSOMAL ABERRATIONS
RFLPS
DNA HYBRIDIZATION
CARCINOGENESIS
DNA
KARYOTYPE
LEUKOCYTES
PATIENTS
TUMOR CELLS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DISEASES
HYBRIDIZATION
MATERIALS
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
550400* - Genetics