Radioiodinated branched-chain fatty acids: substrates for beta oxidation. concise communication. [Rats]

Journal Article · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:5352121

Otto, C A; Brown, L E; Scott, A M

Branched-chain iodinated fatty acids have been proposed for use as myocardial imaging agents. Several ..omega..-iodoalkyl and ..omega..-iodoaryl ..beta..-methyl branched fatty acids have been synthesized and tested in rats. Myocardial activity levels at t = 5 min are affected by chain length for both alkyl and aryl acids, with chain lengths of 16 carbons possessing higher levels of activity than shorter lengths. Branching significantly lowers heart-to-blood ratios relative to straight-chain analogs. The degree of branching also affects radioactivity levels. Monoalkylation at the ..beta.. carbon does not reduce the levels for ..omega..-iodoalkyl fatty acids, but dialkylation reduces the levels significantly. Branching in the ..omega..-iodoaryl series of fatty acids altered the time course of activity in the myocardium from a level of activity decreasing with time for the straight-chain acid to an essentially constant level of activity for the branched analogs.

• Research Organization: Univ. of Michigan, Dearborn
• OSTI ID: 5352121
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HEART
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
METABOLISM
MUSCLES
MYOCARDIUM
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RESONANCE
RODENTS
SYNTHESIS
THYROID
TISSUE DISTRIBUTION
VERTEBRATES