Effect of MPG on radiation-induced odontogenic tissue metaplasia

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Oral Surg., Oral Med., Oral Pathol.; (United States)

DOI:https://doi.org/10.1016/0030-4220(88)90202-2· OSTI ID:5350030

Geist, J R; Kafrawy, A H; Shupe, R E

This investigation monitored the effect of 2-mercaptopropionylglycine (MPG) in reducing radiation damage to the tooth-forming tissues. Fifty rats were exposed to x-ray doses of between 3 and 19 Gy directed toward the maxillary incisor germinal centers. Half of the animals were given an injection of MPG before irradiation, while the other rats were injected with saline solution. Administration of MPG did not significantly reduce the frequency of dentinal niche formation relative to the control teeth. The average lengths and percentage depths of the apicoincisal niches were statistically smaller in the groups treated with MPG. Although statistically significant, the mild protective effect of MPG was not clinically important because damage to the irradiated teeth was still extensive.

• Research Organization: Univ. of Detroit School of Dentistry, MI (USA)
• OSTI ID: 5350030
• Journal Information: Oral Surg., Oral Med., Oral Pathol.; (United States), Vol. 65:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
TEETH
BIOLOGICAL RADIATION EFFECTS
DENTIN
DENTISTRY
RADIATION DOSES
RATS
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
DIGESTIVE SYSTEM
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
MEDICINE
ORAL CAVITY
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals