DISTRIBUTION AND EFFECTS OF STRONTIUM-90 AND X-RADIATION ON THE TEETH AND SURROUNDING STRUCTURES OF THE RAT
Long-Evans rats at the age of 8 months were administered /sup 90/Sr (232 mu C orally or 4.5 mu C intravenously) and simultaneously or later exposed to whole-body doses (400 or 500 r) of x rays. Oral and dental tissues were examined histologically and autoradiologically 9-10 months after /sup 90/Sr administration. In the lower incisor region the /sup 90/Sr was localized in the supporting bone; thin compact bone in the coronai region was heavily laden, while less discrete areas were present in the alveolar bone near the developing root apex. Only slight Sr deposition was seen in the continuousiy growing incisor. The distribution in the upper incisor region followed a similar pattern, with /sup 90/ Sr present in the cortical plates and discrete areas in the alveolar bone. Only a little diffuse deposition was demonstrable in the incisor dentin. In the lower molar region the /sup 90/Sr was present in the alveolar bone proper and cortical plates and to a lesser extent in the cancellous supporting bone. The cementum of molars was heavily laden, while root dentin was only siightly radioactive; hot- spots were observed in coronal dentin. Distribution of /sup 90/Sr in the upper molar region was identical with that in the lower molar region. Discrete areas of radioactivity were found in the secondary dentin below the cusps of the molars. No differences in /sup 90/Sr distribution and no consistent changes in tooth or bone morphology were apparent between the control and x-irradiated groups. Although alveolar bone near the developing incisor roots was heavily contaminated with /sup 90/Sr, there was little incorporation of Sr into the developing denta1 tissues. The findings of marked attrition and incisor hypoplasia in gross examination were substantiated by soft x-ray radiologic studies. The low doses of /sup 90/Sr adminlstered to these adult animals were apparently below the threshoid of dental tissue susceptibility to radiation damage, as seen by the absence of histologic changes. (BBB)
- Research Organization:
- Eastman Dental Dispensary, Rochester, N.Y.
- NSA Number:
- NSA-18-019655
- OSTI ID:
- 4018294
- Journal Information:
- N.Y. State Dental J., Vol. Vol: 28; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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