Effect of X-irradiation on the stomach of the rat

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(89)90066-7· OSTI ID:5347407

Breiter, N; Trott, K R; Sassy, T ^[1]

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1. Universitaet Muenchen (Germany, F.R.)

A model for localized 300 kV X-irradiation of the rat stomach was developed. After irradiation with single doses, three distinct gastric disorders were observed which occurred at different latency times. Acute death 2-3 weeks after irradiation was caused by an erosive and ulcerative gastritis and occurred in all animals given 28.5 Gy without diet, in 17% of the animals given 28.5 Gy plus diet, and in 13% of the animals given 23 Gy. Subacute to chronic fatal disorders 4 weeks to 7 months after irradiation were seen as stomach dilatation and gastroparesis, associated with the replacement of the normal gastric mucosa by a hyperkeratinized multilayered squamous epithelium. These disorders occurred in 40-100% of the animals after doses between 16 Gy and 28.5 Gy (+diet). An ED 50 value of 19.2 Gy (16.5-21.2 Gy, 95% confidence interval) was calculated for this gastroparesis. Late gastric obstruction exceeding 7 months after irradiation was seen in the rats because of profound changes in the gastric wall in 13-18% of the animals after doses between 23 Gy and 14 Gy. In animals surviving these three periods, an atrophic mucosa and intestinal metaplasia developed. From functional and morphohistological studies, it can be concluded that there are differences in the pathogenesis of the fatal radiation damage for each of these periods after irradiation.

• OSTI ID: 5347407
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 17:4; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIGESTIVE SYSTEM DISEASES
RADIOINDUCTION
STOMACH
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MUCOUS MEMBRANES
RADIATION DOSES
RADIATION INJURIES
RATS
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
INJURIES
IONIZING RADIATIONS
MAMMALS
MEMBRANES
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals