Biological effects summary report di(2-ethylhexyl) sebacate
An evaluation of the health effects of di(2-ethylhexyl) sebacate (DEHS) was made to assess its potential use as substitute for di(2-ethylhexyl) phthalate (DEHP), which is used as a test aerosol in quantitative fit testing of respirators. A review of published and unpublished information on toxicity of DEHS was made. The limited amount of data on DEHS indicated that it has a low level of toxicity to laboratory animals. No oral or inhalation toxicity studies on humans were found, but skin sensitization and irritation studies were negative. Insufficeint data exists at present to permit determination of DEHS carcinogenicity. Because of structural similarities of DEHS to DEHP and di(ethylhexyl) adipate, and because these latter two materials have been shown to be carcinogenic in rats and mice, DEHS is not recommended at this time as a DEHP substitute until lack of its carcinogenic potential is confirmed.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5346077
- Report Number(s):
- BNL-51729; ON: DE84005624
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PLASTICIZERS
ACUTE EXPOSURE
BIOLOGICAL EFFECTS
CARCINOGENESIS
INHALATION
METABOLISM
SKIN EFFECT
SEBACIC ACID
ESTERS
MICE
RATS
US OSHA
ANIMALS
CARBOXYLIC ACIDS
DICARBOXYLIC ACIDS
INTAKE
MAMMALS
NATIONAL ORGANIZATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
RODENTS
US DOL
US ORGANIZATIONS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)