Metabolic activity of sodium, measured by neutron activation, in the hands of patients suffering from bone diseases: concise communication
Turnover of sodium in the human hand was studied by neutron activation. Patients suffering from various metabolic abnormalities affecting the skeleton, who were undergoing routine neutron activation for the measurement of calcium, were investigated along with a group of healthy volunteers. Neutron activation labels the sodium atoms simultaneously and with equal probability regardless of the turnover time of individual body compartments. The loss of sodium can be described either by a sum of two exponentials or by a single power function. Distinctions between patients and normal subjects were not apparent from the exponential model but were brought out by the power function. The exponent of time in the latter is a measure of clearance rate. The mean values of this parameter in (a) a group of patients suffering from acromegaly; (b) a group including Paget's disease, osteoporosis, Cushing's disease, and hyperparathyroidism; and (c) a group of healthy subjects, were found to be significantly different from each other.
- Research Organization:
- Hammersmith Hospital, London, England
- OSTI ID:
- 5342888
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:1; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACROMEGALY
ACTIVATION ANALYSIS
ALKALI METALS
BARYONS
BODY
BODY AREAS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
CUSHING SYNDROME
DISEASES
ELEMENTARY PARTICLES
ELEMENTS
ENDOCRINE DISEASES
FERMIONS
HADRONS
HANDS
LIMBS
METABOLISM
METALS
NEUTRONS
NUCLEONS
ORGANS
OSTEOPOROSIS
PATIENTS
RESPONSE MODIFYING FACTORS
SKELETAL DISEASES
SKELETON
SODIUM