Use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease
The limited role of bone scanning in the diagnosis of metabolic bone disease might be considerably improved by accurate quantification of skeletal uptake of the radiopharmaceutical. Using a standard shadow-shield whole-body monitor, we have measured whole-body retention (WBR) of Tc-99m HEDP up to 24 hr in 11 patients with renal osteodystrophy (mean WBR 88.6 percent at 24 hr); in ten patients with Paget's disease (mean 56.9 percent); in seven patients with osteomalacia (mean 40.7 percent); in five patients with primary hyperparathyroidism (mean 50.7 percent); in four patients with osteoporosis (mean 21.2 percent); and in 12 normals (mean 19.2 percent). The osteoporotic group could not be differentiated from the normal group, but the other groups were significantly different from the normal group at 24 hr (p less than 0.002), and each individual result for the 24-hr WBR of Tc-99m HEDP in these groups lay outside our normal range. This test may, therefore, provide a sensitive means of detecting conditions with increased bone turnover. We obtained measurements of plasma activity of Tc-99m HEDP in these patients up to 24 hr, and 4-hr bone to soft-tissue ratios from bone-scan images, but little additional information resulted.
- Research Organization:
- Royal Infirmary, Glasgow
- OSTI ID:
- 5113122
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 19:3
- Country of Publication:
- United States
- Language:
- English
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ISOMERIC NUCLEI
OSTEOPOROSIS
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BETA DECAY RADIOISOTOPES
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INTERMEDIATE MASS NUCLEI
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550601* - Medicine- Unsealed Radionuclides in Diagnostics