Radiation biology, immunologic, and hemorheologic effects of a prostaglandin-leukotriene inhibitor

Thesis/Dissertation · Wed Jan 01 04:00:00 EST 1986

OSTI ID:5336565

Mahafzah, M K

This work examined the effects of a prostaglandin-leukotriene inhibitor (Meclomen) on the radiation-induced proctitis and brain edema in primates, and on the total-body-irradiated Balb/c mice. This work also investigated the radioprotective effect on Meclomen on the radiation-induced mucositis in patients with malignancies. In preliminary animal toxicologic experiments we found that Meclomen at a dose of 20 mg/kg is safe when administered to monkeys and mice. We also found that the most frequent toxic signs, in mice receiving toxic doses, were hypoactivity, irritability, convulsions, and death. We observed that Meclomen minimized the death rate, prolonged the life expectancy, and prevented the microscopic liver changes of Balb/C mice that received total body irradiation. However, the drug had no effect on the LD50/15 of the irradiated mice. Meclomen proved to be a radioprotector against radiation-induced proctitis and brain edema in primates.

• Research Organization: State Univ. of New York, Buffalo (USA)
• OSTI ID: 5336565
• Country of Publication: United States
• Language: English

Related Subjects

560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGY
DISEASES
DRUGS
EXTERNAL IRRADIATION
IRRADIATION
MAMMALS
MICE
MONKEYS
NEOPLASMS
PATIENTS
PRIMATES
RADIOBIOLOGY
RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION