Effects of benzene on erythropoiesis in the fetal mouse
Thesis/Dissertation
·
OSTI ID:5335692
Benzene toxicity in humans and adult animals appears as a functional disturbance of hematopoiesis. The work presented here examined the effects of benzene on the fetal mouse and its blood forming organ, the liver. The study includes the effects on macromolecular synthesis in the fetal liver erythropoietic cells and the general effects of benzene on the development of the fetus. Although biochemical changes were noted in the liver of the fetus when the female was exposed to benzene, no histopathologic changes were found. The effects on DNA and heme synthesis in the fetal liver cell population suggest disturbances in the proliferation and maturation phases of the developing red blood cell. The biochemical perturbations observed in the erythropoietic activity of the fetal mouse liver appeared to have no long term effects on the fetus. It is suggested that the temporary effect on the fetus may be the result of inteplay between an increase in the females' rate of metabolism of benzene and the ability of the fetal liver to recover rapidly from disturbances in the erythropoietic cell cycle. Only when the dosing period was extended from day 11 of gestation to term, and the maternal health appeared to be deteriorating, was the viability of the litter affected.
- OSTI ID:
- 5335692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DNA
ELECTRON MICROSCOPY
ERYTHROCYTES
ERYTHROPOIESIS
FETUSES
GLANDS
HEME
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
LIVER
MAMMALS
MATERIALS
MICE
MICROSCOPY
NUCLEIC ACIDS
ONTOGENESIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DNA
ELECTRON MICROSCOPY
ERYTHROCYTES
ERYTHROPOIESIS
FETUSES
GLANDS
HEME
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
LIVER
MAMMALS
MATERIALS
MICE
MICROSCOPY
NUCLEIC ACIDS
ONTOGENESIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES