Stereoheterotopic metabolism of dibenzothiophene and benz(a)anthracene by Beijerinckia B1
Thesis/Dissertation
·
OSTI ID:5335239
The current studies were initiated to determine the metabolic pathway used by bacteria for the degradation benz(a)anthracene. Previous studies showed that a mutant strain of Beijerinckia strain B8/36, oxidizes benz(a(anthracene to an isometric mixture of cis-dihydrodiols. The results reported in this study represent the first evidence for the cleavage of a benzenoid nucleus in benz(a)anthracene. Physicochemical data is presented which shows that an isomeric mixture of o-hydroxypolyaromatic acids are formed from benz(a)anthracene by the wild type strain of Beijerinckia B1. The evolution of /sup 14/CO/sub 2/ from (12-/sup 14/C)-benz(a)anthracene shows that further metabolism of the o-hydroxypolyaromatic acids can occur. The enzymes responsible for the formation of these metabolites were not induced by benz(a)anthracene. However, biphenyl, m-xylene and salicylate were each effective inducing agents. Since blocked mutants were not available the metabolic pathway was analyzed enzymatically.
- Research Organization:
- Texas Univ., Austin (USA)
- OSTI ID:
- 5335239
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
BENZANTHRACENE
BIOLOGICAL PATHWAYS
CARBON 14 COMPOUNDS
CELL CONSTITUENTS
CELL NUCLEI
CLEAVAGE
CONDENSED AROMATICS
CRYSTAL STRUCTURE
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
METABOLISM
MICROORGANISMS
MICROSTRUCTURE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
THIONAPHTHENES
TRACER TECHNIQUES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
BENZANTHRACENE
BIOLOGICAL PATHWAYS
CARBON 14 COMPOUNDS
CELL CONSTITUENTS
CELL NUCLEI
CLEAVAGE
CONDENSED AROMATICS
CRYSTAL STRUCTURE
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
METABOLISM
MICROORGANISMS
MICROSTRUCTURE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
THIONAPHTHENES
TRACER TECHNIQUES