Management of non-resectable (Stage III) breast cancer

Conference · Sat Sep 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5333033

Sponzo, R W ^[1]; Cunningham, T J; Caradonna, R R; Antemann, R

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1. Albany Regional Cancer Center, NY

Thirteen patients with stage T3b or T4 breast carcinoma were treated with radiation and chemotherapy. The radiation therapy (RT) was given to the involved breast and adjacent nodal areas to a dose of 7000 to 9000 rad over 8 to 10 weeks. The chemotherapy consisted of cyclophosphamide 150 mg/m/sup 2/ and 5FU 300 mg/m/sup 2/ IV days 1 to 5 repeated every 5 weeks and Prednisone 10 mg PO qd (CFP). All patients received 12 cycles of chemotherapy - 6 patients began CFP within one month of completion of RT and 6 received CFP and RT simultaneously. Characteristics of the patients were: mean age 57, menopausal status - 4 pre and 8 post with a mean years post-menopausal of 10. All patients had only evidence of localized disease. Eleven of the 13 patients remain in complete remission with a median duration of complete response of 38+ months. One patient receiving simultaneous CFP and RT relapsed after completion of RT. One patient receiving simultaneous CFP and RT relapsed 2 months after completion of CFP. Local skin toxicity from radiation was significantly greater in those receiving simultaneous CFP and RT. The role of radiation therapy combined with chemotherapy in the management of Stage III breast carcinoma is suggested and this will be explored further in an ECOG cooperative group trial.

• OSTI ID: 5333033
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKYLATING AGENTS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CORTICOSTEROIDS
DISEASES
DRUGS
ENDOXAN
FLUOROURACILS
FRACTIONATED IRRADIATION
GLANDS
GLUCOCORTICOIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IRRADIATION
KETONES
MAMMARY GLANDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PREDNISONE
PREGNANES
PYRIMIDINES
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SKIN
STEROID HORMONES
STEROIDS
THERAPY
URACILS