Half-body and local chest irradiation as consolidation following response to standard induction chemotherapy for disseminated small cell lung cancer: an Eastern cooperative oncology group pilot report

Journal Article · Fri Aug 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90126-1· OSTI ID:5005925

Salazar, O M ^[1]; Creech, R H; Rubin, P; Bennett, J M; Mason, B A; Young, J J; Scarantino, C W; Catalano, R B

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1. Univ. of Rochester, NY

A two-institution Phase II Pilot Study for the Eastern Cooperative Oncology Group (ECOG) used standard induction chemotherapy (cyclophosphamide and CCNU) followed by consolidation radiation therapy (RT) (600 rad of upper half-body irradiation plus 2000 rad in one week of localized chest irradiation) followed by maintenance chemotherapy in patients with extensive small cell bronchogenic carcinoma (SCBC). Nineteen patients were entered and 9 (47%) had partial responses (PR) after induction chemotherapy. No complete responses (CR) were seen. The 10 patients whose disease progressed were ineligible for consolidation RT and died with a short median survival time (MST) of 15 weeks. Of the 9 patients who were consolidated, 7 (78%) had complete responses in the chest; five (63%) became overall complete responders. The MST of all consolidated responders was 44 weeks. At this writing, two of the 5 patients who achieved CR after RT consolidation were alive without disease for more than one year; another patient was alive with disease for almost one year. A control group consisting of patients with extensive SCBC was used for comparison; these patients were treated by the two participating institutions in an earlier ECOG protocol with the same chemotherapy regimen but without RT consolidation.

• OSTI ID: 5005925
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMIDES
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CARBONIC ACID DERIVATIVES
CARCINOMAS
CHEMOTHERAPY
CHEST
COMPARATIVE EVALUATIONS
DISEASES
DRUGS
EARLY RADIATION EFFECTS
ENDOXAN
ENERGY RANGE
EXTERNAL IRRADIATION
HEMIC DISEASES
IRRADIATION
LEUKOCYTES
LEUKOPENIA
LOCAL IRRADIATION
LUNGS
MATERIALS
MEDICINE
METASTASES
MEV RANGE
MEV RANGE 10-100
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SURVIVAL TIME
SYMPTOMS
THERAPY
UREA