Influence of chest radiotherapy in frequency and patterns of chest relapse in disseminated small cell lung carcinoma

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19821001)50:7<1266::AID-CNCR2820500708>3.0.CO;2-0· OSTI ID:6381718

Mira, J G ^[1]; Livingston, R B; Moore, T N; Chen, T; Batley, F; Bogardus, Jr, C R; Considine, B Jr; Mansfield, C M; Schlosser, J; Seydel, H G

---

1. Univ. of Texas Health Science Center at San Antonio

The value of radiotherapy to the chest (RC) in disseminated small cell lung carcinoma (SCLC) has been questioned. Two protocols for disseminated SCLC from the Southwest Oncology Group (SWOG) have been compared. The first one included radiotherapy (RT), 3000 rad in two weeks, to the primary tumor, mediastinum and supraclavicular areas, while the second one deleted any RC. Multidrug chemotherapy (CT) and brain RT were used in both protocols. Nonresponders to CT were removed from the study. Our main findings are as follows: (1) Initial chest relapses (patients with no initial extrathoracic relapse) have increased from 24-55% when RC is not given (P = 0.0001). Overall chest relapse (adding those patients that relapsed simultaneously in the chest plus other sites) in the second protocol was 73%. (2) Amount of response to CT does not influence the chances for relapse. Even complete responders to CT have a high chance for chest relapse. (3) Sites of relapse without RC are mainly in the primary tumor, ipsilateral hilus and mediastinum. (4) With RC, relapses shift to the chest periphery, mostly to the lung outside the radiotherapy field and to the pleura. (5) The two very different CT regimens have produced similar percentages and duration of response. (6) CT schema with periodic reinductions prolongs duration of response and survival over schema with continuous maintenance. Hence, interruption of CT to allow RC does not seem to adversely influence CT efficacy.

• OSTI ID: 6381718
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:7; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
CHEST
COMPARATIVE EVALUATIONS
DISEASES
EPIDEMIOLOGY
FRACTIONATED IRRADIATION
IRRADIATION
LUNGS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SURVIVAL TIME
THERAPY