Toxic effects of cadmium on ciliary activity using a tracheal ring model system

Journal Article · Mon Jan 31 23:00:00 EST 1977 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(77)90009-3· OSTI ID:5332943

Adalis, D ^[1]; Gardner, D E; Miller, F J; Coffin, D L

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1. Ball State Univ., Muncie, IN

Experiments were performed to measure the effect of trace metals on ciliary activity using isolated hamster tracheal rings in an in vitro organ culture system. Dose--time response studies for various Cd concentrations and for lengths of exposure were conducted. Statistically significant reductions in ciliary activity occurred at concentrations as low as 0.006 mM of Cd. Validation of these in vitro results occurred when hamsters were exposed in vivo to a CdCl/sub 2/ aerosol of 2 ..mu..m particles at concentrations of 50 to 1420 ..mu..g/m/sup 3/. The length of time required for complete recovery was also studied following various exposure regimens. Since the effectiveness of the mucociliary escalator depends on normal functioning of the ciliated epithelium, it follows from the data presented that inhalation of this metal can inhibit the normal mucociliary function vital for clearance of agents from the respiratory tract.

• OSTI ID: 5332943
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RECOVERY
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPITHELIUM
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
IN VITRO
IN VIVO
INHALATION
INHIBITION
INTAKE
MAMMALS
MATHEMATICS
METALS
MUCOUS MEMBRANES
ORGANS
PARTICLES
QUANTITY RATIO
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SOLS
STATISTICS
TIME DEPENDENCE
TISSUE CULTURES
TISSUES
TOXICITY
TRACHEA
VERTEBRATES