Cytotoxic effects of singlet oxygen
The toxic effects of gas-phase singlet oxygen, /sup 1/O/sub 2/, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with /sup 1/O/sub 2/ showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary activity occurred at /sup 1/O/sub 2/ concentrations as low as 154 ppb after a 2-hr exposures. Cytological alterations in the mucociliary epithelium were observed in explants exposed to 235 ppb /sup 1/O/sub 2/ or greater. When cytotoxic effects were related to the time of exposure to /sup 1/O/sub 2/, maximum effects occurred after a 4-hr exposure. In vitro recovery studies indicate that ciliary activity returned to normal between 4 an d8 hr after exposure.
- Research Organization:
- IIT Research Institute, Chicago, IL (USA)
- OSTI ID:
- 5101699
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 76; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CHEMICAL STATE
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPITHELIUM
HAMSTERS
MAMMALS
NONMETALS
OXIDIZERS
OXYGEN
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RODENTS
TISSUES
TOXICITY
TRACHEA
VERTEBRATES