Nuclear Medicine Program progress report for quarter ending June 30, 1991

Technical Report · Sun Sep 01 04:00:00 EDT 1991

OSTI ID:5332187

Knapp, Jr, F F; Ambrose, K R; Callahan, A P; McPherson, D W; Mirzadeh, S; Srivastava, P C; Hasan, A; Lambert, C R; Lambert, S J; Rice, D E

In this report the excitation functions for production of gallium-66 via {alpha}-induced nuclear reactions on enriched zinc-66 have been measured with E{sub {alpha}}{le}27.3 Mev and E{sub {alpha}}{le}43.7 MeV employing the stack thin-target technique. In addition, the induced activity of gallium-67 in the same sets of targets allowed an evaluation of the excitation functions of the corresponding nuclear reactions. These preliminary studies have demonstrated that sufficient levels of gallium-66 can be produced by {alpha}-induced reactions on enriched zinc targets. A series of radioiodinated analogues of 1-azabicyclo(2.2.2)oct-3-yl {alpha}-hydroxy-{alpha}, {alpha}-diphenylacetate (QNB) have been prepared. These new analogues include 1-azabicyclo-(2.2.2)oct-3-yl{alpha}-hydroxy-{alpha}-(4-iodophenyl)-{alpha}-methylacetate(2,I-WNA), 1-azabicyclo(2.2.2)oct-3-yl (3-iodo)-xanthene-9-carboxylate (3,I-QNX), and 1-azabicyclo(2.2.2)oct-3-yl {alpha}-hydroxy-{alpha}-(E-1-iodo-1-propen-3-yl)-{alpha}-phenylacetate (4,I-QNP), which have also been radiolabeled with iodine-125 with high specific activity. The biodistribution, brain uptake, and receptor specificity of these new analogues are currently being studied. Shipments of radioactive agents made to collaborators during this period included. One shipment of iodine-125-labeled 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) and tungsten-188/rhenium-188 generator. 16 refs., 7 figs., 1 tab.

• Research Organization: Oak Ridge National Lab., TN (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5332187
• Report Number(s): ORNL/TM-11881; ON: DE92000383
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
ALPHA REACTIONS
ANESTHETICS
ANTIBODIES
ANTIDEPRESSANTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHARGED-PARTICLE REACTIONS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
COCAINE
COMPUTERIZED TOMOGRAPHY
CROSS SECTIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EXCITATION FUNCTIONS
FUNCTIONS
GALLIUM 66
GALLIUM 67
GALLIUM ISOTOPES
HALOGENATION
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINATION
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
LIGANDS
MEASURING METHODS
MEDICINE
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROGRESS REPORT
PROTEINS
PSYCHOTROPIC DRUGS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECEPTORS
RESEARCH PROGRAMS
RHENIUM 188
RHENIUM ISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STABLE ISOTOPES
SYNTHESIS
TARGETS
THERAPY
TISSUE DISTRIBUTION
TOMOGRAPHY
TUNGSTEN 188
TUNGSTEN ISOTOPES
ZINC 64 TARGET
ZINC 66
ZINC ISOTOPES