In vivo evaluation of Z-(R,R)-IQNP as a candidate for the study of M{sub 2} muscarinic receptors by SPECT
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:563340
- Oak Ridge National Lab., TN (United States); and others
The ability to image alternations of M{sub 2} muscarinic receptors is of importance in the study of dementias and heart failure. We have developed a QNB analogue, Z-(R)-1-azabicyclo[2.2.2]oct-3-yl (R)-alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate (Z-(R,R)-IQNP), which demonstrates high in vitro binding affinity for both the M{sub 1} and M{sub 2} muscarinic receptor subtypes.
- DOE Contract Number:
- AC05-96OR22464
- OSTI ID:
- 563340
- Report Number(s):
- CONF-970602--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 38; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
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