Improved risk estimates for carbon tetrachloride. Project status report and technical progress report

Technical Report · Mon Sep 01 04:00:00 EDT 1997

DOI:https://doi.org/10.2172/532505· OSTI ID:532505

Benson, J M; Nikula, K J; Barr, E B ^[1]; Springer, D L; Thrall, K D ^[2]

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1. Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Lovelace Respiratory Research Inst.
2. Pacific Northwest National Lab., Richland, WA (United States)

Carbon tetrachloride (CCl{sub 4}) has been used extensively within the Department of Energy (DOE) nuclear weapons facilities. High levels of CCl{sub 4} at these facilities represent a potential health hazard for workers conducting cleanup operations and for surrounding communities. The overall purpose of these studies is to improve the scientific basis for assessing the health risk associated with human exposure to CCl{sub 4}. Specifically, the authors will determine the toxicokinetics of inhaled and ingested CCl{sub 4} in F344/Crl rats. B6C3F{sub 1} mice, and Syrian hamsters. They will also evaluate species differences in the metabolism of CCl{sub 4} by rats, mice, hamsters, and man. Dose-response relationships will be determined in all these studies. This information will be used to improve the physiologically based pharmacokinetic (PBPK) model for CCl{sub 4} originally developed by Paustenbach et al. (1988) and more recently revised by Thrall and Kenny (1996). The authors will also provide scientific evidence that CCl{sub 4}, like chloroform, is a hepatocarcinogen only when exposure results in cell damage, cell killing, and regenerative cell proliferation.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States)
• Sponsoring Organization: USDOE Office of Environmental Restoration and Waste Management, Washington, DC (United States)
• DOE Contract Number: FC04-96AL76406
• OSTI ID: 532505
• Report Number(s): DOE/AL/76406--T1; ON: DE97009333
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL MODELS
CARBON TETRACHLORIDE
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
LIVER
MAN
METABOLISM
PROGRESS REPORT