Improved risk estimates for carbon tetrachloride. 1998 annual progress report

Technical Report · Mon Jun 01 04:00:00 EDT 1998

DOI:https://doi.org/10.2172/13588· OSTI ID:13588

Benson, J M ^[1]; Springer, D L; Thrall, K D ^[2]

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1. Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (US)
2. Battelle Pacific Northwest National Lab., Richland, WA (US)

'The overall purpose of these studies is to improve the scientific basis for assessing the cancer risk associated with human exposure to carbon tetrachloride. Specifically, the toxicokinetics of inhaled carbon tetrachloride is being determined in rats, mice and hamsters. Species differences in the metabolism of carbon tetrachloride by rats, mice and hamsters is being determined in vivo and in vitro using tissues and microsomes from these rodent species and man. Dose-response relationships will be determined in all studies. The information will be used to improve the current physiologically based pharmacokinetic model for carbon tetrachloride. The authors will also determine whether carbon tetrachloride is a hepatocarcinogen only when exposure results in cell damage, cell killing, and regenerative cell proliferation. In combination, the results of these studies will provide the types of information needed to enable a refined risk estimate for carbon tetrachloride under EPA''s new guidelines for cancer risk assessment.'

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (US); Pacific Northwest National Lab., Richland, WA (US)
• Sponsoring Organization: USDOE Office of Environmental Management (EM), Office of Science and Risk Policy
• OSTI ID: 13588
• Report Number(s): EMSP-54940--98; ON: DE00013588
• Country of Publication: United States
• Language: English

Related Subjects

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ECOLOGY
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HEALTH HAZARDS
Health Hazards
PROGRESS REPORT
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RISK ASSESSMENT
Risk Assessment