Administration of N-nitrosodimethylamine, N-nitrosopyrrolidine, or N'-nitrosonornicotine to nursing rats: their interactions with liver and kidney nucleic acids from sucklings

Journal Article · Sun Jun 01 00:00:00 EDT 1986 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5324748

Diaz Gomez, M I; Tamayo, D; Castro, J A

When nursing Sprague-Dawley rats were treated with (/sup 14/C)N-nitrosodimethylamine ((NDMA) CAS: 62-75-9), N-nitrosopyrrolidine (CAS:930-55-2), or N'-nitrosonornicotine (CAS: 16543-55-8), the liver and kidney DNA from their 14-day-old offspring that had been nursed over a 24-hour period became labeled. Upon analysis, liver DNA from sucklings whose nursing mothers were treated with (/sup 14/C)NDMA showed N7-methylguanine- and O6-methylguanine-altered bases. The results suggest that these nitrosamines, which are present in food, tobacco smoke, and in different environmental sources, are a risk not only for lactating mothers but also for the nursing infants.

• Research Organization: Centro de Investigaciones Toxiocologicas, Buenos Aires, Argentina
• OSTI ID: 5324748
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 6; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
AMINES
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CHEMICAL REACTIONS
CONTAMINATION
DIGESTIVE SYSTEM
DNA
FOOD
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MAMMARY GLANDS
MATERIALS
MILK
NEONATES
NITROSAMINES
NITROSO COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RNA
RODENTS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES