Sublocalization of the human PDGF A-chain gene to chromosome 7, band q11. 23, by in situ hybridization

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · Experimental Cell Research; (United States)

DOI:https://doi.org/10.1016/0014-4827(88)90389-8· OSTI ID:5322875

Stenman, G ^[1]; Rorsman, R; Betsholtz, C ^[2]

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1. Goeteborg Univ. (Sweden)
2. University Hospital, Uppsala (Sweden)

The human platelet-derived growth factor A-chain (PDGFA) locus was mapped by in situ hybridization. By use of human cDNA probes encoding the PDGF A-chain precursor polypeptide the gene was assigned to the proximal long arm of chromosome 7, band q11.23. Of 76 cells with silver grains on chromosome 7, 28% had label over this band. The assignment represents a confirmation and further sublocalization of the PDGFA locus. The location correlates with specific chromosomal abnormalities associated with certain human developmental malformations and neoplasms.

• OSTI ID: 5322875
• Journal Information: Experimental Cell Research; (United States), Journal Name: Experimental Cell Research; (United States) Vol. 178:1; ISSN ECREA; ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DNA
DNA HYBRIDIZATION
GENETIC MAPPING
GROWTH FACTORS
HETEROCHROMOSOMES
HYBRIDIZATION
MAMMALS
MAN
MAPPING
MITOGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RECOMBINANT DNA
VERTEBRATES