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Correlation of chromosome patterns in human leukemic cells with exposure to chemicals and/or radiation. Comprehensive progress report, January 1, 1983-December 31, 1985

Technical Report ·
OSTI ID:5322796

A number of chromosomal abnormalities have been found to occur with significantly regularity in several leukemias. This report describes the chromosomal location of some of these abnormalities, and the possible cellular consequences of these mutations. Specifically evidence is presented that the breakpoint junction on the short arm of No. 9 in the t(9;11) in acute monocytic leukemia lies between the alpha interferon gene normally on No. 9 and an oncogene, c-ets1, on No. 11. In the t(8;21) in acute myeloblastic leukemia, the breakpoint junction on the long arm of No. 8 is between two oncogenes, c-mos on No. 8 and c-ets2 on No. 21 which is translocated to No. 8. With the use of DNA probes and in situ chromosome hybridization, it was shown that two genes related to hematopoietic cell proliferation and differentiation are located in or near to the critical region for No. 5. Thus, granulocytic-macrophage colony stimulating factor is localized to 5q23 to 5q32 and the receptor for macrophage colony stimulating factor is localized to 5q31 to 5q33. The former gene is within the deleted region in all three patients, and the latter in two of three patients whose bone marrow cells have a deletion of No. 5. 19 refs., 3 figs.

Research Organization:
Chicago Univ., IL (USA)
DOE Contract Number:
AC02-80EV10360
OSTI ID:
5322796
Report Number(s):
DOE/EV/10360-4; ON: DE85017124
Country of Publication:
United States
Language:
English

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Related Subjects

550400 -- Genetics
550800 -- Morphology
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
CHROMOSOME LOSSES
CONNECTIVE TISSUE CELLS
DISEASES
DNA
GENETIC MAPPING
HEMIC DISEASES
INTERFERON
KARYOTYPE
LEUKEMIA
LEUKEMOGENESIS
LEUKOCYTES
LOSSES
MAPPING
MATERIALS
METALLOPROTEINS
METALLOTHIONEIN
MOLECULAR BIOLOGY
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ONTOGENESIS
ORGANIC COMPOUNDS
PATHOGENESIS
PATIENTS
PROTEINS
RECOMBINANT DNA
SOMATIC CELLS