Deletion of IRF-1, mapping to chromosome 5q21. 1, in human leukemia and preleukemic myelodysplasia
Journal Article
·
· Science (Washington, D.C.); (United States)
- Univ. of New Mexico School of Medicine, Albuquerque (United States)
- Univ. of California, San Francisco (United States)
- Osaka Univ. (Japan)
- City of Hope Medical Center, Duarte, CA (United States)
- Univ. of Arizona Cancer Center, Tucson (United States)
One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.
- OSTI ID:
- 6660511
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 259:5097; ISSN SCIEAS; ISSN 0036-8075
- Country of Publication:
- United States
- Language:
- English
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