Cytosolic distribution of trace metals and chlorinated hydrocarbon oxygenated metabolistes in fish from coastal southern California
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5321631
Liver and gonad cytosols from four fish species collected from municipal outfall and reference sites were separated by Sephadex G-75 column chromatography into pools containing enzymes (ENZ), metallothionein (MT) and glutathione (GSH). Cadmium (Cd), copper (Cu) and zinc (Zn) were usually lower in fish livers from near the outfall. Most Cd, Cu, and Zn occurred in MT pools of livers and gonads. However, Zn and Cu occurred predominately in the ENZ pools at the lowest observed concentrations. In all species, ENZ-Cu showed positive slopes when regressed against total-cytosolic-Cu. ENZ-Cd seldom showed positive slopes when regressed against total-cytosolic-Cd. Patterns for Zn were the least consistent among species with highest ENZ-Zn slopes in livers with the lowest cytosolic-Zn concentrations. The largest portion of oxygenated-DDT and -PCB metabolites (MTBs) was partitioned into liver GSH pools. Concentrations of MTBs in ENZ pools showed positive slopes when regressed against total-cytosolic- and GSH-MTBs. Results for Cu and MTBs are consistent with the notion of an equilibrium-dependent exchange of these between cytosolic pools with no threshold for toxicity.
- Research Organization:
- Southern California Coastal Water Research Project, Long Beach
- OSTI ID:
- 5321631
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
CADMIUM
CALIFORNIA
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
CONTAMINATION
COPPER
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
FEDERAL REGION IX
FISHES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
LIVER
METABOLITES
METALS
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
SEPARATION PROCESSES
TISSUE DISTRIBUTION
TRACE AMOUNTS
TRANSITION ELEMENTS
USA
VERTEBRATES
ZINC
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
CADMIUM
CALIFORNIA
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
CONTAMINATION
COPPER
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
FEDERAL REGION IX
FISHES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
LIVER
METABOLITES
METALS
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
SEPARATION PROCESSES
TISSUE DISTRIBUTION
TRACE AMOUNTS
TRANSITION ELEMENTS
USA
VERTEBRATES
ZINC