Relationship of cadmium accumulation to zinc or copper concentration in horse liver and kidney

Journal Article · Thu Jun 01 04:00:00 EDT 1989 · Environmental Research; (USA)

DOI:https://doi.org/10.1016/S0013-9351(89)80025-8· OSTI ID:7059170

Koizumi, Naoko; Ninomiya, Ruriko; Fujita, Daisuke; Tsukamoto, Toshiyuki ^[1]; Inoue, Yoshiki ^[2]

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1. Hyogo College of Medicine, Nishinomiya (Japan)
2. Institute of Hyogo Industrial Health, Kobe (Japan)

The concentrations of Cd, Zn, Cu, and metallothionein (MT) in the liver, renal cortex, and renal medulla were determined in 24 male and 15 female younger thoroughbreds (age 27 to 97 months) and two old male horses (age 154 months and 190 months). High correlations were found between Zn and MT in the liver, between Cd and MT in the renal cortex, and between Cd and Zn in the renal cortex, while the correlation between Cd and MT in the liver was low. In the renal medulla, high correlations were found between Cd and Zn, between Zn and Cu, and between Cd and Cu. Therefore, in the liver, the MT concentration is the most highly correlated with the Zn concentration and is not correlated with the Cd concentration unless artificially exposed to Cd. In the renal cortex, the MT and Cd concentrations are very highly correlated with each other. The Zn concentration is about 20 {mu}/g when the Cd concentration in the renal cortex is the lowest.

• OSTI ID: 7059170
• Journal Information: Environmental Research; (USA), Journal Name: Environmental Research; (USA) Vol. 49:1; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL ACCUMULATION
BIOLOGICAL FUNCTIONS
BODY
CADMIUM
COPPER
CORRELATIONS
DIGESTIVE SYSTEM
ELEMENTS
FUNCTIONS
GLANDS
HORSES
KIDNEYS
KINETICS
LIVER
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RETENTION
TRANSITION ELEMENTS
VERTEBRATES
ZINC