Inhibition of platelet function by contrast media: iopamidol and ioxaglate versus iothalamate: work in progress

Conference · Thu Aug 01 04:00:00 EDT 1985 · Radiology; (United States)

OSTI ID:5321378

Rao, A K; Rao, V M; Willis, J; Beckett, C; Steiner, R M

The effects of an ionic contrast agent, meglumine iothalamate (Conray-60), and two newer low-osmolality radiographic contrast media, sodium meglumine ioxaglate (Hexabrix) and iopamidol (B-15,000), on platelet aggregation and secretion responses were studied. All three agents inhibited platelet responses during stimulation with adenosine diphosphate (ADP), epinephrine, and collagen. Platelet function was inhibited by iothalamate at concentrations of 11 mg iodine/ml and above, and by the newer agents at concentrations above 30 mg iodine/ml. Addition of exogenous calcium decreased the iothalamate-induced inhibition of aggregation but did not improve dense granule secretion. These studies indicate that the newer agents inhibit platelet function less than iothalamate does, and that chelation of Ca/sup 2 +/ may not be the major mechanism of platelet inhibition by contrast agents.

• Research Organization: Temple Univ. School of Medicine, Philadelphia, PA
• OSTI ID: 5321378
• Report Number(s): CONF-851152-
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 156:2
• Country of Publication: United States
• Language: English

Related Subjects

550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETAMIDE
AGGLOMERATION
ALKALINE EARTH METAL COMPOUNDS
AMIDES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CALCIUM CHLORIDES
CALCIUM COMPOUNDS
CALCIUM HALIDES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
ETHERS
HALIDES
HALOGEN COMPOUNDS
INHIBITION
IOGLYCAMIC ACID
IOPAMIDOL
LABELLED COMPOUNDS
MATERIALS
MEDICINE
MONOCARBOXYLIC ACIDS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RADIOLOGY