Mechanism of ethanol inhibition of fermentation in Zymomonas mobilis CP4

Journal Article · Tue Oct 01 04:00:00 EDT 1985 · J. Bacteriol.; (United States)

OSTI ID:5319069

Osman, Y A; Ingram, L O

Accumulation of alcohol during fermentation is accompanied by a progressive decrease in the rate of sugar conversion to ethanol. In this study, the authors provided evidence that inhibition of fermentation by ethanol can be attributed to an indirect effect of ethanol on the enzymes of glycolysis involving the plasma membrane. Ethanol decreased the effectiveness of the plasma membrane as a semipermeable barrier, allowing leakage of essential cofactors and coenzymes. This leakage of cofactors and coenzymes, coupled with possible additional leakage of intermediary metabolites en route to ethanol formation, is sufficient to explain the inhibitory effects of ethanol on fermentation in Zymomonas mobilis.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 5319069
• Journal Information: J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 164:1; ISSN JOBAA
• Country of Publication: United States
• Language: English

Related Subjects

550701* -- Microbiology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCONVERSION
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
CELL CONSTITUENTS
CELL MEMBRANES
DAYS LIVING RADIOISOTOPES
ENZYMES
ETHANOL
FERMENTATION
GLYCOLYSIS
HYDROXY COMPOUNDS
INHIBITION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEMBRANES
METABOLISM
MICROORGANISMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
TRITIUM COMPOUNDS
ZYMOMONAS MOBILIS