Effects of maleic acid and uranyl on mercurial diuresis in dogs

Journal Article · Mon Jan 01 00:00:00 EST 1973 · J. Pharmacol. Exp. Ther.; (United States)

OSTI ID:5317847

Nigrovic, V; Koechel, D A; Cafruny, E J

The effects of two nephrotoxic agents were studied in anesthetized dogs undergoing mercurial diuresis. One of the agents, uranyl, accumulates in the kidneys when administered as the acetate salt but does not readily react with sulfhydryl groups. In acute experiments uranyl acetate in doses up to 5 ..mu..mol/kg produced no change in the urinary excretion of sodium or chloride. Uranyl acetate given before the injection of mercury(II) did not reduce the diuretic response to inorganic mercury. The other compound, maleic acid, accumulates in the kidneys and also reacts readily with sulfhydryl groups. The administration of small doses of maleic acid did not change the excretion of sodium but it decreased the excretion of chloride. The administration of maleic acid either before or after the administration of mercury completely abolished the diuretic response. The inhibition occurred without significant changes in urinary pH. Diuretic responses to ethacrynic acid, furosemide, hydrochlorothiazide or acetazolamide were preserved in maleate-treated dogs. Both the lack of any effect of uranyl on mercurial diuresis and the specific inhibition of mercurial diuresis by maleic acid support the presently accepted view that the renal diuretic receptor for mercury(II) has at least one sulfhydryl binding site. Although the inhibition is ascribed to competition between mercury(II) and maleate for binding on the receptor, it is conceivable that the reduction in urinary chloride excretion produced by maleate may be responsible, in part, for refractoriness to mercury(II).

• Research Organization: Medical College of Ohio, Toledo
• OSTI ID: 5317847
• Journal Information: J. Pharmacol. Exp. Ther.; (United States), Vol. 187:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MERCURY
BIOLOGICAL EFFECTS
CHLORIDES
DIURETICS
DOGS
EXPERIMENTAL DATA
GLOMERULI
KIDNEYS
MALEIC ACID
OHIO
POTASSIUM
RENAL CLEARANCE
SODIUM
TRACER TECHNIQUES
URANYL COMPOUNDS
ACTINIDE COMPOUNDS
ALKALI METALS
ANIMALS
BODY
CARBOXYLIC ACIDS
CHLORINE COMPOUNDS
CLEARANCE
DATA
DICARBOXYLIC ACIDS
DRUGS
ELEMENTS
EXCRETION
FEDERAL REGION V
HALIDES
HALOGEN COMPOUNDS
INFORMATION
ISOTOPE APPLICATIONS
MAMMALS
METALS
NORTH AMERICA
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
URANIUM COMPOUNDS
USA
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)