Hydrochlorothiazide-induced /sup 131/I excretion facilitated by salt and water
Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na+ to Cl- to I- excretion indicate that as thiazide administration or sodium chloride intake increases renal Na+ and Cl- excretion, I- reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled I-excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced I-excretion rate as much as eight-fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131I by three- to eightfold, acutely. Within five to seven days after 131I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131I disappearance from plasma, reduced the fecal output of 131I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131I, should therefore facilitate the safe excretion of 131I. This accelerated removal of 131I might be enhanced even more if thyroid uptake of 131I is blocked by administration of potassium iodide, as judged by the greater 131I recovery from thyroidectomized dogs.
- OSTI ID:
- 5102189
- Journal Information:
- J. Clin. Pharmacol.; (United States), Journal Name: J. Clin. Pharmacol.; (United States) Vol. 21:5-6; ISSN JCPCB
- Country of Publication:
- United States
- Language:
- English
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560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DOGS
EXCRETION
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RENAL CLEARANCE
SODIUM CHLORIDES
SODIUM COMPOUNDS
SULFUR COMPOUNDS
SURGERY
THYROIDECTOMY
VERTEBRATES
WATER