Generalized peripheral neuropathy in a dental technician exposed to methyl methacrylate monomer

Journal Article · Mon Jul 01 00:00:00 EDT 1991 · Neurology; (United States)

DOI:https://doi.org/10.1212/WNL.41.7.1112· OSTI ID:5317773

Donaghy, M; Rushworth, G; Jacobs, J M ^[1]

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1. Department of Clinical Neurology, Radcliffe Infirmary, Oxford (England)

A 58-year-old dental prosthetic technician developed generalized sensorimotor peripheral neuropathy. Neurophysiologic studies showed a generalized sensorimotor neuropathy of axonal degeneration type. Examination of a sural nerve biopsy showed a moderately severe axonal neuropathy with loss of large myelinated fibers and unmyelinated axons. There was evidence of slow ongoing degeneration and considerable fiber regeneration. Electron microscopy showed increased numbers of filaments in a few fibers. These findings show resemblances to the nerve changes caused by another acrylic resin, acrylamide. They suggest that the neuropathy may have been caused by 30 years of occupational cutaneous and inhalational exposure to methyl methacrylate monomer since they excluded other recognized causes of neuropathy.

• OSTI ID: 5317773
• Journal Information: Neurology; (United States), Journal Name: Neurology; (United States) Vol. 41:7; ISSN 0028-3878; ISSN NEURA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBOXYLIC ACID ESTERS
DISEASES
ELECTRON MICROSCOPY
ELECTROPHYSIOLOGY
ESTERS
METHACRYLIC ACID ESTERS
METHYL METHACRYLATE
MICROSCOPY
NERVES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PERSONNEL
PHYSIOLOGY
TOXICITY