Positron-emitting radioligands for imaging neuroleptic receptors
Conference
·
OSTI ID:5313838
A series of /sup 18/F-labeled butyrophenones (benperidol, haloperidol, spiroperidol and N-methylspiroperidol) were evaluated in baboons and rats with respect to potential utility as radioligands for studying neuroleptic receptors in the living human brain by positron emission tomography. These compounds were administered to baboons, and the radioactivity distributions to the striatum, and to the cerebellum were determined by PET at times up to 8 hours after isotope injection. 4 refs. (DT)
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5313838
- Report Number(s):
- BNL-36886; CONF-8506187-1; ON: DE85017516
- Country of Publication:
- United States
- Language:
- English
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Syntheses and specific activity determination of no-carrier-added fluorine-18-labeled neuroleptic drugs
Journal Article
·
Mon Dec 31 23:00:00 EST 1984
· Life Sci.; (United States)
·
OSTI ID:6940325
Comparison in animal models of /sup 18/F-spiroperidol and /sup 18/F-haloperidol: potential agents for imaging the dopamine receptor
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Sat Oct 01 00:00:00 EDT 1983
· Life Sci.; (United States)
·
OSTI ID:5217123
Syntheses and specific activity determination of no-carrier-added fluorine-18-labeled neuroleptic drugs
Journal Article
·
Thu Jan 31 23:00:00 EST 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:5781282
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBELLUM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLISM
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PSYCHOTROPIC DRUGS
RADIOISOTOPES
RATS
RODENTS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
TRANQUILIZERS
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CEREBELLUM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLISM
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PSYCHOTROPIC DRUGS
RADIOISOTOPES
RATS
RODENTS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
TRANQUILIZERS
VERTEBRATES