Copper deficiency increases levels of dopamine (DA) and norepinephrine (NE) in ventromedial hypothalamus without altering feeding patterns

Conference · Sun Mar 10 23:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5300764

Seidel, K E; Castonguay, T W; Failla, M L ^[1]

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1. Dept. of Agriculture, Beltsville, MD (United States) Univ. of Maryland, College Park (United States)

Cu deficiency results in altered levels of catecholamines in peripheral tissues and specific regions of the CNS in rodents. Because catecholamines can affect feeding behavior, meal patterns of control and Cu deficient rats were compared using a computerized system. Cu deficiency was induced by feeding dams a low Cu diet beginning at 17d of pregnancy and weaning pups to the same diet. Between 4.5 and 6.5 wk-of-age, rats fed {minus}Cu diet ate fewer meals during the light period than did controls. However, total food intake and meal size during light and dark periods were similar for the two groups. At 6.5 wk-of-age, Cu deficiency was confirmed by stunted growth, low tissue Cu and enlarged hearts. Cardiac CA was increased 4.3-fold in Cu deficient rats, while the NE level in heart of Cu deficient rats was 54% that of control. The concentrations of both DA and NE were increased in ventromedial hypothalamus of Cu deficient rats. These results indicate that alterations in catecholamine status of ventromedial hypothalamus associated with severe Cu deficiency fail to markedly affect feeding behavior.

• OSTI ID: 5300764
• Report Number(s): CONF-9104107--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:4; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
COMPUTER CALCULATIONS
COPPER
DIET
DOPAMINE
DRUGS
ELEMENTS
HORMONES
HYDROXY COMPOUNDS
HYPOTHALAMUS
MAMMALS
METABOLISM
METALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RATS
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES