Copper deficiency increases levels of dopamine (DA) and norepinephrine (NE) in ventromedial hypothalamus without altering feeding patterns

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5300764

Seidel, K E; Castonguay, T W; Failla, M L ^[1]

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1. Dept. of Agriculture, Beltsville, MD (United States) Univ. of Maryland, College Park (United States)

Cu deficiency results in altered levels of catecholamines in peripheral tissues and specific regions of the CNS in rodents. Because catecholamines can affect feeding behavior, meal patterns of control and Cu deficient rats were compared using a computerized system. Cu deficiency was induced by feeding dams a low Cu diet beginning at 17d of pregnancy and weaning pups to the same diet. Between 4.5 and 6.5 wk-of-age, rats fed {minus}Cu diet ate fewer meals during the light period than did controls. However, total food intake and meal size during light and dark periods were similar for the two groups. At 6.5 wk-of-age, Cu deficiency was confirmed by stunted growth, low tissue Cu and enlarged hearts. Cardiac CA was increased 4.3-fold in Cu deficient rats, while the NE level in heart of Cu deficient rats was 54% that of control. The concentrations of both DA and NE were increased in ventromedial hypothalamus of Cu deficient rats. These results indicate that alterations in catecholamine status of ventromedial hypothalamus associated with severe Cu deficiency fail to markedly affect feeding behavior.

• OSTI ID: 5300764
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
BIOLOGICAL EFFECTS
DOPAMINE
BIOSYNTHESIS
NORADRENALINE
COMPUTER CALCULATIONS
DIET
HYPOTHALAMUS
METABOLISM
NUTRITIONAL DEFICIENCY
RATS
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DRUGS
ELEMENTS
HORMONES
HYDROXY COMPOUNDS
MAMMALS
METALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology