Stimulation of phospholipid synthesis by luteinizing hormone in isolated rat granulosa cells
Journal Article
·
· Endocrinology; (United States)
This report describes the effect of LH on phospholipid metabolism in rat granulosa cells isolated from mature Graafian follicles. As indicated by the incorporation of radioactive phosphate, LH specifically stimulated the labeling of phosphatidic acid (PA) and phosphatidylinositol (PI). This effect was observed after 2 min and was more pronounced with further incubation with LH. Increases in PI labeling were correlated with increases in LH-induced progesterone accumulation. LH also increased the tissue concentrations of PI. Addition of exogenous PA or PI, but not other phospholipids, increased progesterone accumulation by granulosa cells. These results indicate that LH has selective effects on phospholipid metabolism in rat granulosa cells which may play a role in ovarian steroidogenesis.
- Research Organization:
- Endocrine Laboratory, University of Miami School of Medicine, Florida
- OSTI ID:
- 5299592
- Journal Information:
- Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 112:6; ISSN ENDOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
ESTERS
GONADOTROPINS
HORMONES
ISOTOPES
LABELLING
LEUKOCYTES
LH
LIGHT NUCLEI
LIPIDS
MAMMALS
MATERIALS
METABOLIC ACTIVATION
METABOLISM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
PHOSPHOLIPIDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PITUITARY HORMONES
RADIOISOTOPES
RATS
RODENTS
SYNTHESIS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
ESTERS
GONADOTROPINS
HORMONES
ISOTOPES
LABELLING
LEUKOCYTES
LH
LIGHT NUCLEI
LIPIDS
MAMMALS
MATERIALS
METABOLIC ACTIVATION
METABOLISM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
PHOSPHOLIPIDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PITUITARY HORMONES
RADIOISOTOPES
RATS
RODENTS
SYNTHESIS
VERTEBRATES