Tissue distribution of bovine /sup 125/I-superoxide dismutase in mice. [Superoxide dismutase]

Journal Article · Wed Dec 01 04:00:00 EST 1976 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:5298726

Petkau, A ^[1]; Chelack, W S; Kelly, K; Barefoot, C; Monasterski, L

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1. Whiteshell Nuclear Research Establishment, Pinawa, Manitoba

Intravenously injected /sup 125/I-bovine superoxide dismutase in mice is essentially cleared from organs in 24 h. The /sup 125/I activity per g of tissue at 1 h varies among organs with the brain and kidneys showing the lowest and highest levels, respectively. Within tissues, degradation occurs so that, at 1 h after administration, 5 to 74 percent of the /sup 125/I activity remains associated with the enzyme, depending on the tissue. A small amount of the labelled enzyme is found in washed cells of thymus, lung, spleen, liver and brain.

• OSTI ID: 5298726
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 15:4; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD SERUM
BODY
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RODENTS
TISSUE DISTRIBUTION
TISSUES
TOXICITY
VERTEBRATES