Disturbances in dental development after total body irradiation in bone marrow transplant recipients

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Oral Surg., Oral Med., Oral Pathol.; (United States)

DOI:https://doi.org/10.1016/0030-4220(88)90189-2· OSTI ID:5297435

Dahlloef, G B; Barr, M; Bolme, P; Modeer, T; Loennqvist, B R; Ringden, O; Heimdahl, A

The dental status of 16 children who had been treated with bone marrow transplantation (BMT) for serious bone marrow diseases was followed for up to 6 years. Several types of disturbances in dental development were observed in children who had been conditioned with total body irradiation (TBI) at 10 Gy before BMT. Thus, impaired root development that caused short V-shaped roots was found in all patients, a complete failure of root development and premature apical closure were found in five patients, enamel hypoplasia was observed in four patients, and microdontia was observed in three patients conditioned with TBI. Patients younger than 6 years of age at BMT exhibited the most severe and extensive dental aberrations. The TBI at 10 Gy appeared to be the major cause of the disturbances found.

• Research Organization: Karolinska Institute, Stockholm (Sweden)
• OSTI ID: 5297435
• Journal Information: Oral Surg., Oral Med., Oral Pathol.; (United States), Journal Name: Oral Surg., Oral Med., Oral Pathol.; (United States) Vol. 65:1; ISSN OSOMA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AGE GROUPS
ANIMAL TISSUES
ANTIMETABOLITES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CHILDREN
DIGESTIVE SYSTEM
DRUGS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
METHOTREXATE
ORAL CAVITY
ORGANS
PATIENTS
RADIATION EFFECTS
TEETH
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION