Accessory function of a small radioresistant spleen cell population in the generation of T-cell-mediated cytotoxicity

Journal Article · Mon Mar 15 04:00:00 EST 1982 · Cell. Immunol.; (United States)

DOI:https://doi.org/10.1016/0008-8749(82)90085-5· OSTI ID:5296667

D'Angeac, A D ^[1]; Reme, T; Pla, M; Colombani, J

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1. Hospital St Eloi, Montpellier, France

A subpopulation of radioresistant splenocytes (RSCs) was examined for its ability to act as accessory cells in the generation of cytotoxic thymus-dependent lymphocytes (CTLs). RSCs provided accessory functions to nylon wool-filtered spleen T cells or mature thymocytes acting as responders to allogeneic spleen T cells or mature thymocytes. The participation of Ia antignes in the accessory process was investigated using anti-Ia sera directed against the products of I-A and/or I-E/C subregions. We found that RSC accessory function was dependent upon cells expessing I-A or I-E/C antigens. Preincubation of spleen T cells regardless of whether RSCs were allogeneic, or semisyngeneic to the stimulator T cells.

• OSTI ID: 5296667
• Journal Information: Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 68:1; ISSN CLIMB
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL KILLING
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
IMMUNE SERUMS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
RADIOSENSITIVITY
SOMATIC CELLS
SPLEEN CELLS