Uptake and intracellular distribution of (/sup 35/S)trithiomolybdate in bovine liver in vivo
Journal Article
·
· J. Inorg. Biochem.; (United States)
(/sup 35/S) trithiomolybdate was administered intravenously to a group of four steer at two dose rates, 1 and 26 mg Mo per animal. Radioactivity appeared rapidly in the liver and was distributed in all the subcellular fractions examined. Examination by Sephadex G-100 gel-filtration of the cytosol fraction showed that distinct /sup 35/S-binding protein peaks were present. The protein-bound radioactivity was displaceable and was identified as (/sup 35/S)thiomolybdates. No radioactivity eluted with metallothionein, but /sup 35/S was associated with the high molecular weight copper fraction, eluted in the void volume of the column, which increased transiently after the administration of the higher dose. It was suggested that the presence of protein-bound thiomolybdates in the liver gave rise to new ligands, which altered the equilibrium of copper between the different metal-binding proteins. This might be similar to the alteration in the copper-binding of albumin produced by the presence of thiomolybdates.
- Research Organization:
- Jiangsu Agricultural Univ. (People's Republic of China)
- OSTI ID:
- 5295297
- Journal Information:
- J. Inorg. Biochem.; (United States), Journal Name: J. Inorg. Biochem.; (United States) Vol. 31:2; ISSN JIBID
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CATTLE
CHROMATOGRAPHY
COPPER
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
IN VIVO
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
LIGANDS
LIGHT NUCLEI
LIVER
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
MOLECULAR WEIGHT
MOLYBDENUM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RUMINANTS
SEPARATION PROCESSES
SULFUR 35
SULFUR ISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CATTLE
CHROMATOGRAPHY
COPPER
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
IN VIVO
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
LIGANDS
LIGHT NUCLEI
LIVER
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
MOLECULAR WEIGHT
MOLYBDENUM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RUMINANTS
SEPARATION PROCESSES
SULFUR 35
SULFUR ISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES