Influence of overall treatment time in a fractionated total lymphoid irradiation as an immunosuppressive therapy in allogeneic bone marrow transplantation in mice

Journal Article · Mon Nov 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90450-3· OSTI ID:5295217

Waer, M ^[1]; Ang, K K; Vandeputte, M; Van der Schueren, E

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1. Univ. of Leuven, Belgium

Three groups of C/sub 57//BL/Ka mice received total lymphoid irradiation (TLI) in a total dose of 34 Gy in three different fractionation schedules. The tolerance of all different schedules was excellent. No difference in the peripheral white blood cell and lymphocyte counts nor the degree of immunosuppression as measured by phytohaemaglutinin or concanavalin A induced blastogenesis and mixed lymphocyte reaction were observed at the end of the treatment and up to 200 days. When bone marrow transplantation was performed one day after the end of each schedule, chimerism without signs of graft versus host disease was induced in all the groups. However, from the results in a limited number of animals it seems that concentrated schedules were less effective for chimerism induction. It has been demonstrated that it is possible to reduce drastically the overall treatment time for TLI before bone marrow transplantation. Further investigations are necessary in order to determine the optimal time-dose-fractionation factors and the different perameters involved in the transplantation.

• OSTI ID: 5295217
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CHIMERAS
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
IMMUNOTHERAPY
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MICE
MOSAICISM
ORGANS
PARTIAL BODY IRRADIATION
RADIATION CHIMERAS
RADIOINDUCTION
RODENTS
THERAPY
TIME DEPENDENCE
TISSUES
TRANSPLANTS
VERTEBRATES