A stochastic model of hormesis

Journal Article · Sun Aug 01 04:00:00 EDT 1993 · Mathematical Biosciences; (United States)

DOI:https://doi.org/10.1016/0025-5564(93)90066-J· OSTI ID:5293584

Yakovlev, A Yu; Tsodikov, A D ^[1]; Bass, L ^[2]

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1. St. Petersburg Technical Univ. (Russian Federation)
2. Univ. of Queensland, Brisbane (Australia)

In order to describe the life-prolonging effect of some agents that are harmful at higher doses, ionizing radiations in particular, a stochastic model is developed in terms of accumulation and progression of intracellular lesions caused by the environment and by the agent itself. The processes of lesion repair, operating at the molecular and cellular level, are assumed to be responsible for this hormesis effect within the framework of the proposed model. Properties of lifetime distributions, derived for analysis of animal experiments with prolonged and acute irradiation, are given special attention. The model provides efficient means of interpreting experimental findings, as evidenced by its application to analysis of some published data on the hormetic effects of prolonged irradiation and of procaine on animal longevity. 51 refs., 2 figs., 1 tabs.

• OSTI ID: 5293584
• Journal Information: Mathematical Biosciences; (United States), Journal Name: Mathematical Biosciences; (United States) Vol. 116:2; ISSN MABIAR; ISSN 0025-5564
• Country of Publication: United States
• Language: English

Related Subjects

560150* -- Radiation Effects on Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
990200 -- Mathematics & Computers
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
INJURIES
IONIZING RADIATIONS
LIFE SPAN
MATHEMATICAL MODELS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
REPAIR