Hormonally induced tumors of the reproductive system of parabiosed male rats

Journal Article · Mon Oct 01 00:00:00 EDT 1979 · Cancer Res.; (United States)

OSTI ID:5290107

Brown, C E; Warren, S; Chute, R N; Ryan, K J; Todd, R B

Parabiosis of intact male rats to castrated males or oophorectomized females for a period of approximately 20 months resulted in three interstitial cell tumors of the testis. When unilateral nephrectomy was added to the parabiotic procedure in ten pairs, eight interstitial cell tumors of the testis and four adenocarcinomas of the prostate occurred in the target male parabionts. These changes were preceded by elevations in luteinizing and follicle-stimulating hormone levels in the serum of the castrates and high levels of testosterone and, to a lesser degree, of androstenedione in the target partners developing the tumors.

• Research Organization: Harvard Univ., Boston, MA
• OSTI ID: 5290107
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMAL CELLS
ANIMALS
BODY
CARCINOGENESIS
CARCINOMAS
CASTRATION
DISEASES
FSH
GLANDS
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
KETONES
LH
MALE GENITALS
MALES
MAMMALS
MEDICINE
MOSAICISM
NEOPLASMS
NEPHRECTOMY
ORGANIC COMPOUNDS
ORGANS
PARABIOSIS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
PROSTATE
RATS
REPRODUCTION
RODENTS
STEROID HORMONES
STEROIDS
SURGERY
TESTES
TESTOSTERONE
TUMOR CELLS
VERTEBRATES