Association of the Philadelphia chromosome and 5q- in secondary blood disorder

Journal Article · Mon Feb 01 00:00:00 EST 1988 · Cancer Genet. Cytogenet.; (United States)

DOI:https://doi.org/10.1016/0165-4608(88)90192-6· OSTI ID:5288048

Dastugue, N; Demur, C; Pris, F; Bugat, R; Attal, M; Bourrouillou, G; Colombies, P

A patient developed a secondary blood disorder 7 years after radiotherapy for a gastric lymphoma. The initial myelodysplastic syndrome evolved to a myeloproliferative phase with transient polycythemia, progressive thrombocythemia, and hyperleukocytosis. Chromosome analysis performed in the terminal phase showed del(5)(q13q31),t(9;22)(q34;q11), and a complex rearrangement involving chromosomes number2 and number3. A correlation between chromosomal abnormalities and hematologic findings could be established. In this case, we have assumed that the Philadelphia translocation is a late event, due to prior mutagen exposure, and its association with a common secondary abnormality (5q-), followed by a progressively developing myeloproliferative phase. Furthermore, the association of Ph and 5q- in a single clone seems to indicate that the same stem cell is affected by these two abnormalities.

• Research Organization: Laboratoire Central d'Hematologie et de Genetique, C.H.U. Purpan-Toulouse (France)
• OSTI ID: 5288048
• Journal Information: Cancer Genet. Cytogenet.; (United States), Vol. 30:2
• Country of Publication: United States
• Language: English

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LYMPHOMAS
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