Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome

Journal Article · Fri Aug 01 04:00:00 EDT 1980 · Blood; (United States)

OSTI ID:5127049

Roth, D G; Richman, C M; Rowley, J D

A patient with severe anemia, reticulocytopenia, and erythroid hyperplasia of the bone marrow developed fatal acute nonlymphocytic leukemia after 3 yr. A Philadelphia chromosome with the typical 9/22 translocation was identified by banding techniques in a small number of bone marrow cells throughout the preleukemic phase of the illness (14% to 38% of the metaphases) and during the acute transformation (50%). Granulocytic colony formation in vitro was abnormal in the preleukemic phase. The diagnosis of chronic granulocytic leukemia was excluded on the basis of clinical and laboratory findings. The identification of the Ph/sup 1/ chromosome in this form of chronic myelodysplastic syndrome (preleukemia) provides a new example of a hematologic disorder predisposing to acute leukemia in which this chromosomal abnormality occurs.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 5127049
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 56:2; ISSN BLOOA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550600* -- Medicine
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
BANDING TECHNIQUES
BODY
BONE MARROW
CFU
CHROMOSOMES
DIAGNOSIS
DISEASES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IN VITRO
LEUKEMIA
NEOPLASMS
ORGANS
PATIENTS
PHILADELPHIA CHROMOSOME
SYMPTOMS
TISSUES