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Protection of intestinal damage by pretreatment with cytarabine (cytosine arabinoside)

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5276115
;
The circumstances in which cytarabine (cytosine arabinoside) ''protects'' intestinal epithelial stem cells against radiation have been investigated. Special attention has been given to this protective effect with radiation doses in the clinically used range in order to determine whether the protective effect might be of use in radiotherapy. It has been shown that 12 hours after cytarabine the D/sub 0/ and extrapolation number are increased when large single doses of radiation are used. To determine the effect of cytarabine at lower doses, it is necessary to use a second irradiation as an ''assay'' dose. By this means it is shown that there is more protection than can be accounted for by the change in D/sub 0/ and extrapolation number at the time of the first dose. Evidence is presented indicating that the rate of stem cell regeneration is not increased by cytarabine pretreatment. Finally, the relation between intestinal protection, bone marrow stem cell enhanced recovery and improved animal survival as a result of cytarabine pretreatment is discussed.
Research Organization:
Inst. of Cancer Research, Surrey, England
OSTI ID:
5276115
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BONE MARROW CELLS
CELL CULTURES
CLONE CELLS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
NUMERICAL DATA
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RECOVERY
RESPONSE MODIFYING FACTORS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TIME DEPENDENCE
WHOLE-BODY IRRADIATION