Quinolinic acid lesion of nucleus accumbens reduces D sub 1 but not D sub 2 dopamine receptors: An autoradiographic study

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90609-F· OSTI ID:5272317

Filloux, F; Richards, T J; Huff, G F ^[1]; Wamsley, J K ^[2]

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1. Univ. of Utah, Salt Lake City (USA)
2. Neuropsychiatric Research Inst., Fargo, ND (USA)

Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axonsparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D{sub 1} receptors (as labeled by ({sup 3}H)SCH 23390). Contrarily, no appreciable decrement in D{sub 2} receptors (labeled by ({sup 3}H)raclopride) could be identified within the same region of the NAcc. The findings support the view that accumbens D{sub 1} receptors are located postsynaptically on neurons or their processes, while D{sub 2} receptors within this nucleus are primarily located on afferent terminals.

• OSTI ID: 5272317
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 48:26; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISTRIBUTION
DOPAMINE
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
KINETICS
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PROTEINS
REACTION KINETICS
RECEPTORS
SUBCELLULAR DISTRIBUTION
SYMPATHOMIMETICS
TRITIUM COMPOUNDS