PET demonstrates different behaviour of striatal dopamine D-1 and D-2 receptors in early Parkinson's disease

Journal Article · Sat Dec 01 04:00:00 EST 1990 · Journal of Neuroscience Research; (USA)

DOI:https://doi.org/10.1002/jnr.490270409· OSTI ID:5800991

Rinne, J O; Laihinen, A; Nagren, K B; Bergman, J; Solin, O; Haaparanta, M; Ruotsalainen, U; Rinne, U K ^[1]

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1. Univ. of Turku (Finland)

Striatal dopamine D-1 receptor binding was investigated in vivo with positron emission tomography (PET) in five patients with early Parkinson's disease using {sup 11}C-SCH 23390. All patients had predominantly unilateral symptoms and showed a significant reduction in the accumulation of {sup 18}F-6-F-DOPA in the striatum contralateral to the symptoms. None of the patients had received any antiparkinsonian medication. The striatal and cerebellar radioactivity was measured and corresponding striatum/cerebellum ratios were counted. The mean striatum/cerebellum ratio of {sup 11}C-SCH 23390 binding was symmetric between the hemispheres. By contrast, the striatum/cerebellum ratio of ({sup 11}C)raclopride binding, labelling dopamine D-2 receptors, was increased significantly in the hemisphere contralateral to the symptoms as compared with the opposite hemisphere. Thus, the present results show that the behaviour of striatal D-1 and D-2 receptors is different in early Parkinson's disease.

• OSTI ID: 5800991
• Journal Information: Journal of Neuroscience Research; (USA), Journal Name: Journal of Neuroscience Research; (USA) Vol. 27:4; ISSN JNRED; ISSN 0360-4012
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AMINO ACIDS
AROMATICS
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BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
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CENTRAL NERVOUS SYSTEM
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FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
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LIGHT NUCLEI
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
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NEUROREGULATORS
NUCLEI
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ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RECEPTORS
SYMPATHOMIMETICS
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