c-fos and c-myc expression in human endothelial cells as a function of different culture conditions

Journal Article · Wed Jan 31 23:00:00 EST 1990 · Experimental Cell Research; (United States)

DOI:https://doi.org/10.1016/0014-4827(90)90320-A· OSTI ID:5269434

Lampugnani, M G; Polentarutti, N; Pedenovi, M; Mantovani, A; Dejana, E; Colotta, F ^[1]

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1. Instituto di Ricerche Farmacologiche Mario Negri, Milan (Italy)

Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.

• OSTI ID: 5269434
• Journal Information: Experimental Cell Research; (United States), Journal Name: Experimental Cell Research; (United States) Vol. 186:2; ISSN ECREA; ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BODY
CELL CULTURES
CELL PROLIFERATION
CYTOLOGICAL TECHNIQUES
ENDOTHELIUM
GENE REGULATION
GENES
MAMMALS
MAN
MESSENGER-RNA
NUCLEIC ACIDS
ONCOGENES
ORGANIC COMPOUNDS
PRIMATES
RNA
TISSUES
VERTEBRATES